Invitrogen

Ghrelin Monoclonal Antibody (45)

View all (26) Ghrelin antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

ABS 050-45-02

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, lambda

Class

Monoclonal

Type

Antibody

Clone

45

Immunogen

Synthetic human Ser3-octanoyl ghrelin-28.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.01 mg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4

Contains

15mM sodium azide

Storage conditions

4°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2536228

Product Specific Information

Specificity: ABS 050-45-02 binds human ghrelin and des-acyl ghrelin, and showed ~5% cross-Specificity with rat ghrelin in a sandwich ELISA using ABS 052-121 as biotinylated detection antibody.

Reactivity: ABS 050-45-02 binds human ghrelin in solution. ABS 050-45-02 can be used as a capture antibody in a sandwich ELISA using biotinylated detection antibody ABS 052-121-02.

NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL

Target Information

GHRL encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an the ligand for the growth hormone secretagogue receptor type 1 and is involved in regulating growth hormone release. Ghrelin has an appeptite-stimulating effect and induces adiposity and stimulates gastric acid secretion. Obestatin may be the ligand for the orphan G protein-coupled receptor GPR39 and is involved in satiety and can have an appetite-reducing effect resulting in decreased food intake.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AMCBX1; Appetite-regulating hormone; FIP-3; FIP3; Fip3p; ghrelin 27; ghrelin 28; ghrelin, growth hormone secretagogue receptor ligand; ghrelin/obestatin; ghrelin/obestatin preprohormone; Growth hormone secretagogue; Growth hormone-releasing peptide; IKK-gamma; In2c-preproghrelin; IP; IP1; IP2; IPD2; Motilin-related peptide; NEMO; OTTHUMP00000207794; OTTHUMP00000207795; OTTHUMP00000207796; OTTHUMP00000207798; prepro-appetite regulatory hormone; preproghrelin; Protein M46

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Gene Aliases: GHRL; MTLRP; UNQ524/PRO1066

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UniProt ID: (Human) Q9UBU3

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Entrez Gene ID: (Human) 51738

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Function(s)
G-protein coupled receptor binding protein binding growth hormone-releasing hormone activity protein tyrosine kinase activator activity ghrelin receptor binding
Process(es)
activation of MAPK activity gastric acid secretion negative regulation of endothelial cell proliferation glucose metabolic process G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration actin polymerization or depolymerization adult feeding behavior response to hormone hormone-mediated signaling pathway dendrite development negative regulation of angiogenesis growth hormone secretion positive regulation of insulin secretion regulation of response to food positive regulation of appetite negative regulation of interleukin-1 beta production negative regulation of locomotion positive regulation of multicellular organism growth regulation of cell proliferation negative regulation of circadian sleep/wake cycle, REM sleep negative regulation of tumor necrosis factor biosynthetic process negative regulation of apoptotic process cortisol secretion response to estrogen negative regulation of interleukin-6 biosynthetic process positive regulation of circadian sleep/wake cycle, non-REM sleep negative regulation of insulin secretion decidualization negative regulation of inflammatory response cartilage development positive regulation of corticotropin secretion positive regulation of cortisol secretion positive regulation of synapse assembly excitatory postsynaptic potential positive regulation of growth hormone secretion positive regulation of growth hormone receptor signaling pathway positive regulation of protein tyrosine kinase activity negative regulation of energy homeostasis positive regulation of energy homeostasis
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